EFFICACY OF RABIES VACCINE WITH DIFFERING ANTIGEN

PAYLOADS ON PRE AND SIMULATED POST-EXPOSURE

PROPHYLAXIS IN CATTLE

Sargam Arya, Sahzad, S. Shebannavar, T.V.S. Rao* aad G.S. Reddy
Brilliant Bio Pharma Private Limited, l.D.A, Pashamylaram, Hyderabad, Telangana, India

ABSTRACT

pre- and post-exposure prnphylaus (PrEP and PEP) have been used to control the losses incurred due to rabies. Unlike in humans, no firm PrEP and PEP guidelines are available for control of rabies in animals. In this study, healthy caHle calves were vaccinated with either single (PrEP regime) or five doses (simulated PEP regime) of rabies vaccine with a potency uf 1.2 c IlT/dose or 2.7 lU/dose. Vaccine was administered on Day 0,3, 7,14 and 28 as per “Essen’ regimen. The serum was collected ^ from aU the vaccinated cattle un 0,7,14, 28 and 60 days post inoculation (dpi) and virus neutralization antibody (VNA) levels ^ were determined by fluorescent antibody virus neutralisatinn test (FAVN). The results reveal that vaccination with single 3 dose of 2.7 lU/dose ofrabies vaccine induced higher VNA in serum compared mth 1.2 lU/dose vaccine. Comparison of serum I antibody levels between animals vaccinated with single dose of high antigen payload (2.7 lU/dose) and multiple vaccination I with 1.2 lU/dose vaccine showed significantly higher antibody levels in the former at 14, 28 and 60 dpi intervals. From this ^ study, it is concluded that the protective levels ofiiDinuDity in cattle can be achieved with high antigen payload vaccine with 5 either two or three doses, respectively, in PrEP and simulated PEP programs.

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